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Article

Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.

European journal of immunology - 1 Nov 2016

Fuchs Sebastian, Kaiser-Labusch Petra, Bank Julia, Ammann Sandra, Kolb-Kokocinski Anja, Edelbusch Christine, Omran Heymut, Ehl Stephan

Abstract excerpt

Tyrosine kinase 2 (TYK2) associates with interferon (IFN) alpha receptor, IL-10 receptor (IL-10R) beta and other cytokine receptor subunits for signal transduction, in response to various cytokines, including type-I and type-III IFNs, IL-6, IL-10, IL-12 and IL-23. Data on TYK2 dependence on cytokine responses and in vivo consequences of TYK2 deficiency are inconsistent. We investigated a TYK2 deficient patient,...

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Source

Identifiers

PMID: 27615517
DOI: 10.1002/eji.201646519

Genes

TYK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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