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Article

Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2011

Sabino Valentina, Cottone Pietro, Blasio Angelo, Iyer Malliga R, Steardo Luca, Rice Kenner C, Conti Bruno, Koob George F, Zorrilla Eric P

Abstract excerpt

Sigma (σ) receptors have been implicated in the behavioral and motivational effects of alcohol and psychostimulants. Sigma receptor antagonists reduce the reinforcing effects of alcohol and excessive alcohol intake in both genetic (alcohol-preferring rats) and environmental (chronic alcohol-induced) models of alcoholism. The present study tested the hypothesis that pharmacological activation of σ-receptors...

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Identifiers

PMID: 21346735
DOI: 10.1038/npp.2011.5
PMCID: PMC3079320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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