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Article

Genetic Instability of Live, Attenuated Human Immunodeficiency Virus Type 1 Vaccine Strains

1 Feb 1999

Abstract excerpt

Live, attenuated viruses have been the most successful vaccines in monkey models of human immunodeficiency virus type 1 (HIV-1) infection. However, there are several safety concerns about using such an anti-HIV vaccine in humans, including reversion of the vaccine strain to virulence and recombination with endogenous retroviral sequences to produce new infectious and potentially pathogenic viruses. Because...

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PMID: 9882315
DOI: 10.1128/jvi.73.2.1138-1145.1999

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