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Article

RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence.

Journal of virology - 1 Feb 1992

Chumakov K M, Norwood L P, Parker M L, Dragunsky E M, Ran Y X, Levenbook I S

Abstract excerpt

Mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC) was used to study sequence heterogeneity and stability in attenuated poliovirus type 3 at positions in which the vaccine virus differs from its wild-type progenitor. Of seven genomic positions tested, only two (positions 472 and 2493) show nucleotide heterogeneity. Propagation of the vaccine virus in cell cultures leads to rapid...

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Identifiers

PMID: 1309923
DOI: 10.1128/JVI.66.2.966-970.1992
PMCID: PMC240798

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