RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence.

doi:10.1128/JVI.66.2.966-970.1992

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Article

RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence.

Journal of virology - 1 Feb 1992

Chumakov K M, Norwood L P, Parker M L, Dragunsky E M, Ran Y X, Levenbook I S

Abstract excerpt

Mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC) was used to study sequence heterogeneity and stability in attenuated poliovirus type 3 at positions in which the vaccine virus differs from its wild-type progenitor. Of seven genomic positions tested, only two (...

Topics

Animals
Base Sequence
Genetic Variation
Genome, Viral
Macaca
Molecular Sequence Data
Mutation
Poliovirus
Poliovirus Vaccine, Oral
Polymerase Chain Reaction
Restriction Mapping
Virulence

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