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Article

Stability of RNA virus attenuation approaches.

Vaccine - 9 Mar 2011

Kenney Joan L, Volk Sara M, Pandya Jyotsna, Wang Eryu, Liang Xiaodong, Weaver Scott C

Abstract excerpt

The greatest risk from live-attenuated vaccines is reversion to virulence. Particular concerns arise for RNA viruses, which exhibit high mutation frequencies. We examined the stability of 3 attenuation strategies for the alphavirus, Venezuelan equine encephalitis virus (VEEV): a traditional, point mutation-dependent attenuation approach exemplified by TC-83; a rationally designed, targeted-mutation approach...

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Share to Genome, Viral
Share to Genomic Instability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sequence Analysis, RNA

Share to Vaccines, Attenuated

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Source

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Identifiers

PMID: 21288800
DOI: 10.1016/j.vaccine.2011.01.055
PMCID: PMC3060670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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