Live attenuated AIDS viruses as vaccines: promise or peril?

doi:10.1111/j.1600-065x.1999.tb01335.x

Article

Live attenuated AIDS viruses as vaccines: promise or peril?

1 Aug 1999

Abstract excerpt

Live attenuated viruses can provide vaccine protection against various viral illnesses. A number of live attenuated strains of the simian immunodeficiency virus (SIV) or related lentiviruses have been evaluated in primate models as vaccine candidates against AIDS. Impressive efficacy was observed for some viruses, most notably SIV strains with deletions in the nef-gene. Sterilizing immunity was seen against...

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