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Article

Engineering attenuated virus vaccines by controlling replication fidelity.

Nature medicine - 1 Feb 2008

Vignuzzi Marco, Wendt Emily, Andino Raul

Abstract excerpt

Long-lasting protection against viral infection is best achieved by vaccination with attenuated viruses. Obtaining stably attenuated vaccine strains has traditionally been an empirical process, which greatly restricts the number of effective vaccines for viral diseases. Here we describe a rational approach for engineering stably attenuated viruses that can serve as safe and effective vaccines. Our approach...

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PMID: 18246077
DOI: 10.1038/nm1726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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