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Article

A sequence immediately upstream of the plus-strand primer is essential for plus-strand DNA synthesis of the Saccharomyces cerevisiae Ty1 retrotransposon.

Nucleic acids research - 1 Dec 1999

Wilhelm M, Heyman T, Boutabout M, Wilhelm F X

Abstract excerpt

Priming of plus-strand DNA is a critical step in reverse transcription of retroviruses and retrotransposons. All retroelements use an RNase H-resistant oligoribonucleotide spanning a purine-rich sequence (the polypurine tract or PPT) to prime plus-strand DNA synthesis. Plus-strand DNA synthesis of the yeast Saccharomyces cerevisiae Ty1-H3 retrotransposon is initiated at two sites, PPT1 and PPT2, located at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10556309
DOI: 10.1093/nar/27.23.4547
PMCID: PMC148741

Genes

PPT2
PPT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A sequence immediately upstream of the plus-strand primer is essential for plus-strand DNA synthesis of the Saccharomyces cerevisiae Ty1 retrotransposon.PMID 10556309Read ↗

The central PPT of the yeast retrotransposon Ty1 is not essential for transposition.Semantic proximity Read ↗

Plus-strand strong-stop DNA synthesis in retrotransposon Ty1.Semantic proximity Read ↗

Polypurine tract formation by Ty1 RNase H.Semantic proximity Read ↗

The yeast retrotransposon Ty5 uses the anticodon stem-loop of the initiator methionine tRNA as a primer for reverse transcription.Semantic proximity Read ↗

Yeast Ty1 retrotransposon: the minus-strand primer binding site and a cis-acting domain of the Ty1 RNA are both important for packaging of primer tRNA inside virus-like particles.Semantic proximity Read ↗

Interaction of the Ty3 reverse transcriptase thumb subdomain with template-primer.Semantic proximity Read ↗

RNA branching and debranching in the yeast retrovirus-like element Ty1.Semantic proximity Read ↗

The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

Effects of 3' untranslated region mutations on plus-strand priming during moloney murine leukemia virus replication.Semantic proximity Read ↗

A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.Semantic proximity Read ↗

Saccharomyces cerevisiae RNA lariat debranching enzyme, Dbr1p, is required for completion of reverse transcription by the retrovirus-like element Ty1 and cleaves branched Ty1 RNAs.Semantic proximity Read ↗

Extended interactions between the primer tRNAi(Met) and genomic RNA of the yeast Ty1 retrotransposon.Semantic proximity Read ↗

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