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Article

Mutational analysis of the reactive site loop of Streptomyces metalloproteinase inhibitor, SMPI.

Journal of biochemistry - 1 Jan 1999

Hiraga K, Seeram S S, Tate S, Tanaka N, Kainosho M, Oda K

Abstract excerpt

Streptomyces metalloproteinase inhibitor (SMPI) is the only inhibitor to show "standard mechanism inhibition" against metalloproteinases. SMPI is a globular protein with an exposed loop containing the reactive site, C64-V65. To analyze the importance of basic residues in the reactive site loop of...

Topics

Bacterial Proteins
Binding Sites
Circular Dichroism
Disulfides
Magnetic Resonance Spectroscopy
Metalloendopeptidases
Models, Molecular
Mutation
Protein Conformation
Streptomyces
Structure-Activity Relationship

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Identifiers

PMID: 9880818
DOI: 10.1093/oxfordjournals.jbchem.a022260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9880818-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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