Article
Identification of the blood coagulation factor interacting sequences in staphylococcal superantigen-like protein 10.
Biochemical and biophysical research communications - 25 Mar 2017
Itoh Saotomo, Takii Takemasa, Onozaki Kikuo, Tsuji Tsutomu, Hida Shigeaki
Abstract excerpt
Staphylococcal superantigen-like proteins (SSLs) are a family of exoproteins of Staphylococcus aureus. We have shown that SSL10 binds to vitamin K-dependent coagulation factors and inhibits blood coagulation induced by recalcification of citrated plasma. SSL10 was revealed to bind to coagulation factors via their γ-carboxyglutamic acid (Gla) domain. In this study we attempted to identify the responsible sequence...
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