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Article

A molecular model of the serine protease domain of activated protein C: application to the study of missense mutations causing protein C deficiency.

British journal of haematology - 1 Jun 1993

Wacey A I, Pemberton S, Cooper D N, Kakkar V V, Tuddenham E G

Abstract excerpt

A molecular model of the serine protease domain of protein C was constructed by standard comparative methods. Individual missense mutations were inserted into the model and plausible explanations for their interference with protein C structure/function were derived through consideration of location, steric effects and protein stability. A hydrophilic cluster of many Arg and Lys residues, found adjacent to the...

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Identifiers

PMID: 8398833
DOI: 10.1111/j.1365-2141.1993.tb03067.x

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