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Article

Structures of importance for the stability of antiplasmin as studied by site-directed mutagenesis.

Thrombosis research - 1 Jan 2006

Wang Haiyao, Pap Sarolta, Wiman Björn

Abstract excerpt

Human antiplasmin, a fast-acting inhibitor of plasmin in plasma, belongs to the serpin super-family of proteins. Like other members of this family, antiplasmin has a scissile peptide bond exposed within a reactive centre loop, typically present at the surface of the molecule. Antiplasmin is stable at neutral pH, but at acidic pH or at elevated temperatures it rapidly becomes inactivated. Data regarding "native"...

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Identifiers

PMID: 16378834
DOI: 10.1016/j.thromres.2005.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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