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Article

In silico mutations and molecular dynamics studies on a winged bean chymotrypsin inhibitor protein.

Protein engineering - 1 Jul 2003

Dasgupta Jhimli, Sen Udayaditya, Dattagupta J K

Abstract excerpt

Winged bean chymotrypsin inhibitor (WCI) has an intruding residue Asn14 that plays a crucial role in stabilizing the reactive site loop conformation. This residue is found to be conserved in the Kunitz (STI) family of serine protease inhibitors. To understand the contribution of this scaffolding residue on the stability of the reactive site loop, it was mutated in silico to Gly, Ala, Ser, Thr, Leu and Val and...

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PMID: 12915726
DOI: 10.1093/protein/gzg070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In silico mutations and molecular dynamics studies on a winged bean chymotrypsin inhibitor protein.PMID 12915726Read ↗

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