Article
Preparation of a novel streptokinase mutant with improved stability.
Thrombosis and haemostasis - 1 May 1998
Shi G Y, Chang B I, Su S W, Young K C, Wu D H, Chang L C, Tsai Y S, Wu H L
Abstract excerpt
The novel mutant streptokinase, SK-K59E, can activate human plasminogen as efficiently as the purified commercially available streptokinase. Several peptide bonds including Lys59-Ser60 in native streptokinase were hydrolyzed in reaction with plasmin and peptides of small molecular masses were gen...
Topics
- Enzyme Stability
- Fibrinolysin
- Humans
- Mutation
- Peptide Fragments
- Plasminogen
- Plasminogen Activators
- Streptokinase