Article
Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 1998
Kress C, Vandormael-Pournin S, Baldacci P, Cohen-Tannoudji M, Babinet C
Abstract excerpt
The inbred mouse strain DDK carries a conditional early embryonic lethal mutation that is manifested when DDK females are crossed to males of other inbred strains but not in the corresponding reciprocal crosses. It has been shown that embryonic lethality could be assigned to a single genetic locu...
Topics
- Alleles
- Animals
- Cell Line
- Crosses, Genetic
- Embryo, Mammalian
- Embryonic Development
- Female
- Homozygote
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Inbred Strains
- Mutation
- Pregnancy
- Stem Cells