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Article

A transgene-induced mitotic arrest mutation in the mouse allelic with Oligosyndactylism.

Genetics - 1 Dec 1996

Pravtcheva D D, Wise T L

Abstract excerpt

Oligosyndactylism (Os) is a radiation-induced mutation on mouse chromosome 8 associated with early postimplantation lethality in homozygotes and abnormal development of the limbs and kidneys in heterozygotes. The recessive lethal effect of Os is due to a mitotic block of the embryonic cells that becomes apparent at the blastocyst stage, but it is not known if the heterozygous effect of Os is due to...

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Identifiers

PMID: 8978060
DOI: 10.1093/genetics/144.4.1747
PMCID: PMC1207724

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