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Article

The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 1999

Pardo-Manuel de Villena F, de la Casa-Esperón E, Verner A, Morgan K, Sapienza C

Abstract excerpt

The DDK syndrome is a polar, early embryonic lethal phenotype caused by incompatibility between a maternal factor of DDK origin and a paternal gene of non-DDK origin. Both maternal factor and paternal gene have been mapped to the Om locus on mouse Chromosome (Chr) 11. The paternal contribution to the syndrome has been shown to segregate as a single locus. Although the inheritance of the maternal contribution has...

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PMID: 10337624
DOI: 10.1007/s003359901029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om.PMID 10337624Read ↗

The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.Semantic proximity Read ↗

Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome.Semantic proximity Read ↗

BALB/c alleles at modifier loci increase the severity of the maternal effect of the "DDK syndrome".Semantic proximity Read ↗

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice.Semantic proximity Read ↗

The polar-lethal Ovum mutant gene maps to the distal portion of mouse chromosome 11.Semantic proximity Read ↗

Modification of survival rate of mouse embryos developing in heterozygous females for ovum mutant gene.Semantic proximity Read ↗

Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome.Semantic proximity Read ↗

Recapitulation of the ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos.Semantic proximity Read ↗

Rescue of the mouse DDK syndrome by parent-of-origin-dependent modifiers.Semantic proximity Read ↗

Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids.Semantic proximity Read ↗

Female mice of DDK strain are fully fertile in the intersubspecific crosses with Mus musculus molossinus and M. m. castaneus.Semantic proximity Read ↗

Male-offspring-specific, haplotype-dependent, nonrandom cosegregation of alleles at loci on two mouse chromosomes.Semantic proximity Read ↗

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