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Article

Modification of survival rate of mouse embryos developing in heterozygous females for ovum mutant gene.

Biology of reproduction - 1 Apr 2000

Zhao W D, Chung H J, Wakasugi N

Abstract excerpt

The DDK syndrome (polar infertility) is caused by an incompatibility system due to the ovum mutant (Om) locus. For brevity, the following gene symbols are used in the present report: DDK allele, Om; C57BL/6Cr allele, +. In this investigation, we first attempted to introduce the Om allele of DDK strain into the genetic background of C57BL/6Cr strain. The attempt resulted in the production of no young at the third...

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Identifiers

PMID: 10727253
DOI: 10.1095/biolreprod62.4.857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Modification of survival rate of mouse embryos developing in heterozygous females for ovum mutant gene.PMID 10727253Read ↗

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice.Semantic proximity Read ↗

Recapitulation of the ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos.Semantic proximity Read ↗

BALB/c alleles at modifier loci increase the severity of the maternal effect of the "DDK syndrome".Semantic proximity Read ↗

The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om.Semantic proximity Read ↗

Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome.Semantic proximity Read ↗

Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation.Semantic proximity Read ↗

Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome.Semantic proximity Read ↗

Female mice of DDK strain are fully fertile in the intersubspecific crosses with Mus musculus molossinus and M. m. castaneus.Semantic proximity Read ↗

The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.Semantic proximity Read ↗

Rescue of the mouse DDK syndrome by parent-of-origin-dependent modifiers.Semantic proximity Read ↗

Inheritance of a meiotic abnormality that causes the ovulation of primary oocytes and the production of digynic triploid mice.Semantic proximity Read ↗

Female germline expression of OVO transcription factor bridges Drosophila generations.Semantic proximity Read ↗

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