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Article

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice.

Journal of genetics - 1 Jun 2016

Tan Jing, Song Gen Di, Song Jia Sheng, Ren Shi Hao, Li Chun Li, Zheng Zhen Yu, Zhao Wei Dong

Abstract excerpt

A striking infertile phenotype has been discovered in the DDK strain of mouse. The DDK females are usually infertile when crossed with males of other inbred strains, whereas DDK males exhibit normal fertility in reciprocal crosses. This phenomenon is caused by mutation in the ovum (Om) locus on chromosome 11 and known as the DDK syndrome. Previously, some research groups reported that the embryonic mortality...

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Share to Chromosomes, Mammalian
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Genes, Lethal

Share to Genes, Modifier

Share to Infertility, Female

Share to Mice, Inbred Strains

Source

Identifiers

PMID: 27350672
DOI: 10.1007/s12041-016-0633-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice.PMID 27350672Read ↗

Modification of survival rate of mouse embryos developing in heterozygous females for ovum mutant gene.Semantic proximity Read ↗

Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome.Semantic proximity Read ↗

BALB/c alleles at modifier loci increase the severity of the maternal effect of the "DDK syndrome".Semantic proximity Read ↗

The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om.Semantic proximity Read ↗

Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome.Semantic proximity Read ↗

Recapitulation of the ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos.Semantic proximity Read ↗

Female mice of DDK strain are fully fertile in the intersubspecific crosses with Mus musculus molossinus and M. m. castaneus.Semantic proximity Read ↗

The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.Semantic proximity Read ↗

Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.Semantic proximity Read ↗

A <i>mdg4</i> Retrotransposon Screen for X-linked Female Sterile Alleles and its Relationship with the Transcription Factor OVOSemantic proximity Read ↗

A mdg4 retrotransposon screen for X-linked female sterile alleles and its relationship with the transcription factor OVO.Semantic proximity Read ↗

Rescue of the mouse DDK syndrome by parent-of-origin-dependent modifiers.Semantic proximity Read ↗

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