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Article

Silencing subdomains of v-ErbA interact cooperatively with corepressors: involvement of helices 5/6.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2000

Busch K, Martin B, Baniahmad A, Martial J A, Renkawitz R, Muller M

Abstract excerpt

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression by TR in the absence of ligand is mediated by an active silencing mechanism. The oncogene v-ErbA is a variant form of TR unable to bind hormone and thus acts as a constitutive repressor. Functional studies and...

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Identifiers

PMID: 10674394
DOI: 10.1210/mend.14.2.0415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Silencing subdomains of v-ErbA interact cooperatively with corepressors: involvement of helices 5/6.PMID 10674394Read ↗

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Very strong correlation between dominant negative activities of mutant thyroid hormone receptors and their binding avidity for corepressor SMRT.Semantic proximity Read ↗

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