Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function.

Abstract excerpt

The avian erythroblastosis virus v-erbA oncogene is imprecisely derived from a cellular gene (c-erbA) encoding a thyroid hormone receptor: the v-erbA protein has sustained both small terminal deletions and internal amino acid sequence changes relative to c-erbA. We report here that one of these missense differences between v- and c-erbA proteins, located in a zinc finger DNA binding domain, has dramatic effects...

Topics

• Amino Acid Sequence
• Animals
• Avian Leukosis
• Avian Leukosis Virus
• Base Sequence
• Cell Transformation, Viral
• Chickens
• DNA, Viral
• Erythroid Precursor Cells
• Molecular Sequence Data
• Mutation