Article
Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.
Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2006
Kamsteeg Erik-Jan, Hendriks Giel, Boone Michelle, Konings Irene B M, Oorschot Viola, van der Sluijs Peter, Klumperman Judith, Deen Peter M T
Abstract excerpt
To regulate mammalian water homeostasis, arginine-vasopressin (AVP) induces phosphorylation and thereby redistribution of renal aquaporin-2 (AQP2) water channels from vesicles to the apical membrane. Vice versa, AVP (or forskolin) removal and hormones activating PKC cause AQP2 internalization, but the mechanism is unknown. Here, we show that a fraction of AQP2 is modified with two to three ubiquitin moieties in...
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