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Article

Ubiquitylation and activation of a Rab GTPase is promoted by a β₂AR-HACE1 complex.

Journal of cell science - 1 Jan 2014

Lachance Véronik, Degrandmaison Jade, Marois Sébastien, Robitaille Mélanie, Génier Samuel, Nadeau Stéphanie, Angers Stéphane, Parent Jean-Luc

Abstract excerpt

We and others have shown that trafficking of G-protein-coupled receptors is regulated by Rab GTPases. Cargo-mediated regulation of vesicular transport has received great attention lately. Rab GTPases, which form the largest branch of the Ras GTPase superfamily, regulate almost every step of vesicle-mediated trafficking. Rab GTPases are well-recognized targets of human diseases but their regulation and the...

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PMID: 24190883
DOI: 10.1242/jcs.132944

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