Article
Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.
Cell - 26 Jan 1996
Hicke L, Riezman H
Abstract excerpt
Binding of alpha factor to Ste2p, a G protein-coupled plasma membrane receptor, activates a signal transduction pathway and stimulates endocytosis of the receptor-ligand complex. Ligand binding also induces ubiquitination of the Ste2p cytoplasmic tail. Protein ubiquitination is required for stimulated endocytosis of Ste2p, as internalization is 5- to 15-fold slower in ubc mutants that lack multiple...
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