Article
Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.
Cell - 26 Jan 1996
Hicke L, Riezman H
Abstract excerpt
Binding of alpha factor to Ste2p, a G protein-coupled plasma membrane receptor, activates a signal transduction pathway and stimulates endocytosis of the receptor-ligand complex. Ligand binding also induces ubiquitination of the Ste2p cytoplasmic tail. Protein ubiquitination is required for stimu...
Topics
- Amino Acid Sequence
- Biological Transport
- Carboxypeptidases
- Cathepsin A
- Cysteine Endopeptidases
- Endocytosis
- Hydrolases
- Ligands
- Ligases
- Lysine
- Mating Factor
- Molecular Sequence Data
- Molecular Weight
- Multienzyme Complexes
- Mutation
- Peptides
- Proteasome Endopeptidase Complex
- Receptors, Mating Factor