TP53 structure-function relationships in metastatic castrate-sensitive prostate cancer and the impact of APR-246 treatment.

doi:10.1002/pros.24629

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Article

TP53 structure-function relationships in metastatic castrate-sensitive prostate cancer and the impact of APR-246 treatment.

The Prostate - 1 Jan 2024

Hoang Tung, Sutera Philip, Nguyen Triet, Chang Jinhee, Jagtap Shreya, Song Yang, Shetty Amol C, Chowdhury Dipanwita D, Chan Aaron, Carrieri Francesca A, Hathout Lara, Ennis Ronald, Jabbour Salma K, Parikh Rahul, Molitoris Jason, Song Daniel Y, DeWeese Theodore, Marchionni Luigi, Ren Lei, Sawant Amit, Simone Nicole, Lafargue Audrey, Van Der Eecken Kim, Bunz Fred, Ost Piet, Tran Phuoc T, Deek Matthew P

Abstract excerpt

PURPOSE: Despite well-informed work in several malignancies, the phenotypic effects of TP53 mutations in metastatic castration-sensitive prostate cancer (mCSPC) progression and metastasis are not clear. We characterized the structure-function and clinical impact of TP53 mutations in mCSPC. PATIENTS AND METHODS: We performed an international retrospective review of men with mCSPC who underwent next-generation...

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PMID: 37812042
DOI: 10.1002/pros.24629

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TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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