Article
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
Cancer cell - 14 Oct 2013
Fan Qi-Wen, Cheng Christine K, Gustafson W Clay, Charron Elizabeth, Zipper Petra, Wong Robyn A, Chen Justin, Lau Jasmine, Knobbe-Thomsen Christiane, Weller Michael, Jura Natalia, Reifenberger Guido, Shokat Kevan M, Weiss William A
Abstract excerpt
EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes transformation has been difficult because of autocrine and paracrine loops triggered by EGFRvIII alone or in heterodimers with wild-type EGFR. Here, we document coexpression of EGFR and EGFRvIII in primary human glioblastoma that drives...
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