Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant.

doi:10.1016/s0166-3542(98)00051-5

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Article

Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant.

Antiviral research - 1 Dec 1998

Faizi Khan R, Mori S, Eizuru Y, Kumura Ishii K, Minamishima Y

Abstract excerpt

We isolated a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) from a laboratory strain, AD169, and analysed the mutant. Attempts were also made to identify directly the mutated gene. The 50% inhibitory concentration (IC50) of GCV for the mutant strain was five times higher than that of t...

Topics

Antiviral Agents
Cell Line
Cytomegalovirus
Drug Resistance, Microbial
Ganciclovir
Humans
Mutation
Phosphotransferases (Alcohol Group Acceptor)
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Virus Replication

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