Article
[Analysis of ganciclovir-resistant cytomegalovirus].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jan 1998
Eizuru Y
Abstract excerpt
The ganciclovir(GCV)-resistant human cytomegaloviruses(HCMV) result from the mutation(s) in either the UL97 phosphotransferase gene, or UL54 DNA polymerase gene, or both. Majority of clinical isolates of GCV-resistant mutant had mutations in the UL97 gene. Because the mutations in the UL97 gene cluster in two regions, sudomain VI and IX, it is almost possible to identify a GCV-resistant mutant by PCR-based DNA...
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