Article
The p38 pathway provides negative feedback for Ras proliferative signaling.
The Journal of biological chemistry - 15 Dec 2000
Chen G, Hitomi M, Han J, Stacey D W
Abstract excerpt
Ras activates three mitogen-activated protein kinases (MAPKs) including ERK, JNK, and p38. Whereas the essential roles of ERK and JNK in Ras signaling has been established, the contribution of p38 remains unclear. Here we demonstrate that the p38 pathway functions as a negative regulator of Ras proliferative signaling via a feedback mechanism. Oncogenic Ras activated p38 and two p38-activated protein kinases,...
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