Article
Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.
The Journal of biological chemistry - 16 Dec 1994
Ikezu T, Okamoto T, Murayama Y, Okamoto T, Homma Y, Ogata E, Nishimoto I
Abstract excerpt
G alpha i2 is a tissue-specific proto-oncogene product, whose activated mutant gip2 induces transformation through less defined downstream pathways. We found that c-fos promoter is a target of gip2 in multiple kinds of cells. Serum response element was shown to be the positive enhancer element th...
Topics
- Animals
- Base Sequence
- Cell Line
- Cell Transformation, Neoplastic
- DNA Primers
- Enhancer Elements, Genetic
- GTP-Binding Protein alpha Subunit, Gi2
- GTP-Binding Protein alpha Subunits, Gi-Go
- GTP-Binding Proteins
- Gene Expression Regulation, Neoplastic