Article
Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.
The Journal of biological chemistry - 16 Dec 1994
Ikezu T, Okamoto T, Murayama Y, Okamoto T, Homma Y, Ogata E, Nishimoto I
Abstract excerpt
G alpha i2 is a tissue-specific proto-oncogene product, whose activated mutant gip2 induces transformation through less defined downstream pathways. We found that c-fos promoter is a target of gip2 in multiple kinds of cells. Serum response element was shown to be the positive enhancer element that mediates gip2-induced c-fos expression. We further demonstrated that gip2 stimulates the negative silencer activity...
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