Article
Genetic analysis of PHIP intestinal mutations in MutaMouse.
Mutagenesis - 1 Nov 1998
Lynch A M, Gooderham N J, Davies D S, Boobis A R
Abstract excerpt
The mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was investigated in male MutaMouse mice administered 20 mg/kg per o.s. for 4 days and killed 7 days later. Genomic DNA was extracted from liver, kidney and small and large intestine and the mutation frequency (MF) at the l...
Topics
- Animals
- Carcinogens
- Imidazoles
- Intestines
- Kidney
- Liver
- Male
- Mice
- Mice, Transgenic
- Mutagens
- Mutation
- Sequence Analysis, DNA
- Transgenes
- beta-Galactosidase