Article
The cII locus in the MutaMouse system.
Environmental and molecular mutagenesis - 1 Jan 1999
Swiger R R, Cosentino L, Shima N, Bielas J H, Cruz-Munoz W, Heddle J A
Abstract excerpt
Here, we report the first application and characterization of the cII locus as a mutational target for use with the Muta(trade mark)Mouse system for quantifying somatic mutations in vivo. This locus can be analyzed for mutations using positive selection and is identical in sequence to the cII in the Big Blue((R)) Mouse. The cII displays similar spontaneous (5.5 x 10(-5)) and induced mutation frequencies when...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.