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Article

Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.

Journal of affective disorders - 1 Jun 2013

Hatzimanolis Alex, Vitoratou Silia, Mandelli Laura, Vaiopoulos Chrysostomos, Nearchou Finiki A, Stefanis Costas N, Serretti Alessandro, Stefanis Nicholas C

Abstract excerpt

BACKGROUND: Several polymorphic variants within the catechol-O-methyltransferase (COMT) gene locus have been associated with a number of diverse psychiatric phenotypes including affective disorders. COMT enzyme participates in metabolic pathways involving brain catecholamines, as well as steroid hormones such as estrogens. Given the suggested mood enhancing role of estrogens and the higher prevalence of...

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Source

Identifiers

PMID: 23351565
DOI: 10.1016/j.jad.2012.12.018

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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