Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women.

The international journal of neuropsychopharmacology - 1 Jun 2004

Domschke Katharina, Freitag Christine M, Kuhlenbäumer Gregor, Schirmacher Anja, Sand Philipp, Nyhuis Peter, Jacob Christian, Fritze Jürgen, Franke Petra, Rietschel Marcella, Garritsen Henk S, Fimmers Rolf, Nöthen Markus M, Lesch Klaus-Peter, Stögbauer Florian, Deckert Jürgen

Abstract excerpt

Panic disorder is an anxiety disorder with an estimated heritability of up to 48%. Pharmacological and genetic studies suggest that genes coding for proteins involved in the catecholaminergic system might be relevant for the pathogenesis of the disease. In the present study, we genotyped a single nucleotide polymorphism (472G/A=V158M) in the coding region of the catechol-O-methyl-transferase (COMT) gene in 115...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Gene Frequency

Share to Panic Disorder

Share to Polymorphism, Genetic

Share to Psychiatric Status Rating Scales

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 15009906
DOI: 10.1017/S146114570400416X

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women.PMID 15009906Read ↗

Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.Semantic proximity Read ↗

Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity.Semantic proximity Read ↗

Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22.Semantic proximity Read ↗

Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder.Semantic proximity Read ↗

Serotonin-2A receptor and catechol-O-methyltransferase polymorphisms in panic disorder.Semantic proximity Read ↗

Meta-analysis on the association of the COMT Val158Met variant with preeclampsia risk.Semantic proximity Read ↗

The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Association between Val158Met functional polymorphism in the COMT gene and risk of preeclampsia in a Chinese population.Semantic proximity Read ↗

Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women.Semantic proximity Read ↗

Association between COMT Val158Met polymorphism and preeclampsia in the Chinese Han population.Semantic proximity Read ↗

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic StudiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.