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Article

The role of mismatch repair in the prevention of base pair mutations in <i>Saccharomyces cerevisiae</i>

22 Dec 1998

Abstract excerpt

In most organisms, the mismatch repair (MMR) system plays an important role in substantially lowering mutation rates and blocking recombination between nonidentical sequences. In Saccharomyces cerevisiae, the products of three genes homologous to Escherichia coli mutS-MSH2, MSH3, and MSH6-function in MMR by recognizing mispaired bases. To determine the effect of MMR on single-base pair mismatches, we have...

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PMID: 9860995
DOI: 10.1073/pnas.95.26.15487

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