Article
Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jul 1999
Harfe B D, Jinks-Robertson S
Abstract excerpt
Frameshift mutations occur when the coding region of a gene is altered by addition or deletion of a number of base pairs that is not a multiple of three. The occurrence of a deletion versus an insertion type of frameshift depends on the nature of the transient intermediate structure formed during DNA synthesis. Extrahelical bases on the template strand give rise to deletions, whereas extrahelical bases on the...
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