Article
Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Feb 1991
Detloff P, Sieber J, Petes T D
Abstract excerpt
Heteroduplexes formed between DNA strands derived from different homologous chromosomes are an intermediate in meiotic crossing over in the yeast Saccharomyces cerevisiae and other eucaryotes. A heteroduplex formed between wild-type and mutant genes will contain a base pair mismatch; failure to repair this mismatch will lead to postmeiotic segregation (PMS). By analyzing the frequency of PMS for various mutant...
Topics
- Alleles
- Base Composition
- Chromosomes, Fungal
- DNA Repair
- DNA, Fungal
- Genes, Fungal
- Genetic Carrier Screening
- Meiosis
- Mutation
- Nucleic Acid Heteroduplexes
- Recombination, Genetic
