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Reconstitution of long and short patch mismatch repair reactions using <i>Saccharomyces cerevisiae</i> proteins

1 Nov 2013

Abstract excerpt

A problem in understanding eukaryotic DNA mismatch repair (MMR) mechanisms is linking insights into MMR mechanisms from genetics and cell-biology studies with those from biochemical studies of MMR proteins and reconstituted MMR reactions. This type of analysis has proven difficult because reconstitution approaches have been most successful for human MMR whereas analysis of MMR in vivo has been most advanced in...

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PMID: 24187148
DOI: 10.1073/pnas.1318971110

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