Article
IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.
Nature immunology - 1 Nov 2001
Biedermann T, Zimmermann S, Himmelrich H, Gumy A, Egeter O, Sakrauski A K, Seegmüller I, Voigt H, Launois P, Levine A D, Wagner H, Heeg K, Louis J A, Röcken M
Abstract excerpt
Immunity to infection with intracellular pathogens is regulated by interleukin 12 (IL-12), which mediates protective T helper type 1 (TH1) responses, or IL-4, which induces TH2 cells and susceptibility. Paradoxically, we show here that when present during the initial activation of dendritic cells (DCs) by infectious agents, IL-4 instructed DCs to produce IL-12 and promote TH1 development. This TH1 response...
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