Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine.

doi:10.1038/sj.mp.4000425

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Article

Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine.

Molecular psychiatry - 1 Nov 1998

Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, Catalano M

Abstract excerpt

Depression with psychotic features has been shown to respond to selective serotonin reuptake inhibitors (SSRIs). The serotonin transporter (5-HTT) is a prime target for SSRIs. A functional polymorphism within the promoter region of the 5-HTT gene, leading to different transcriptional efficiency,...

Topics

Antidepressive Agents, Second-Generation
Carrier Proteins
Depressive Disorder
Drug Therapy, Combination
Female
Fluvoxamine
Genotype
Humans
Male
Membrane Glycoproteins
Membrane Transport Proteins
Middle Aged
Nerve Tissue Proteins
Pindolol
Polymorphism, Genetic
Predictive Value of Tests
Promoter Regions, Genetic
Serotonin Antagonists

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Open in PubMed

Identifiers

PMID: 9857976
DOI: 10.1038/sj.mp.4000425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9857976-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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