Article
Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease.
Molecular psychiatry - 1 May 2001
Mössner R, Henneberg A, Schmitt A, Syagailo Y V, Grässle M, Hennig T, Simantov R, Gerlach M, Riederer P, Lesch K P
Abstract excerpt
Idiopathic Parkinson's disease (PD) is a common neurodegenerative disorder with prominent motor symptoms. However, depression is common in PD, affecting about 40% of PD patients. Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic...
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