Article
Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder.
Human psychopharmacology - 1 May 2016
Iga Jun-Ichi, Watanabe Shin-Ya, Numata Shusuke, Umehara Hidehiro, Nishi Akira, Kinoshita Makoto, Inoshita Masatoshi, Shimodera Shinji, Fujita Hirokazu, Ohmori Tetsuro
Abstract excerpt
The serotonin transporter (5HTT) may be associated with the pathogenesis of major depressive disorder (MDD). The 5HTT-linked polymorphic region (5HTTLPR) genotype may determine how levels of 5HTT mRNA are influenced by promoter methylation. We examined the association of 5HTT gene methylation, which influences gene expression, and the 5HTTLPR genotype before antidepressant treatment and expression before and...
Topics
- Adult
- Antidepressive Agents
- Case-Control Studies
- DNA Methylation
- Depressive Disorder, Major
- Female
- Follow-Up Studies
- Gene Expression Regulation
- Genotype
- Humans