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Article

Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

15 Mar 2006

Abstract excerpt

Dysfunction of cholinergic basal forebrain (CBF) neurons of the nucleus basalis (NB) is a cardinal feature of Alzheimer's disease (AD) and correlates with cognitive decline. Survival of CBF neurons depends upon binding of nerve growth factor (NGF) with high-affinity (trkA) and low-affinity (p75(NTR)) neurotrophin receptors produced within CBF neurons. Since trkA and p75(NTR) protein levels are reduced within CBF...

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Alzheimer's disease research and treatments
Cholinesterase and Neurodegenerative Diseases
Nuclear Receptors and Signaling

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16539663
DOI: 10.1111/j.1471-4159.2006.03764.x

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Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's diseasePMID 16539663Read ↗

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