Article
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death.
Neurobiology of disease - 1 Apr 2003
Su Joseph H, Anderson Aileen J, Cribbs David H, Tu Christina, Tong Liqi, Kesslack Patrick, Cotman Carl W
Abstract excerpt
It has recently been suggested that neuronal cell death in response to many brain insults may be mediated by the upregulation of tumor necrosis factor receptor (TNFR) family members and their ligands. In the present study, we investigated whether the expression of the TNFR family death domain receptor, Fas, and its ligand, FasL, is altered in association with neuropathology and activated caspase markers in...
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