Article
Defective escape mutants of HIV.
Journal of theoretical biology - 21 Dec 1994
Berry R M, Nowak M A
Abstract excerpt
The virological literature presents two broad types of defective virus mutants that can alter the outcome of viral infection. In some infections, defective interfering particles reduce the replication of wild-type virus and lead to an attenuated or persistent infection. In other cases, very specific and highly pathogenic defective mutants lead to virulent disease in the presence of a much less pathogenic but...
Topics
- Defective Viruses
- HIV
- HIV Infections
- Humans
- Models, Biological
- Mutation
- Virus Replication