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Article

Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2000

Goodman J E, Lavigne J A, Hengstler J G, Tanner B, Helzlsouer K J, Yager J D

Abstract excerpt

A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene causes a 3- to 4-fold reduction in enzyme activity and has been associated with an increased risk of breast cancer. This increased risk may be attributable to a decreased ability of the protein encoded by the low-activity allele (COMT(L)) to methylate and inactivate catechol estrogens, which have been implicated in...

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Source

Identifiers

PMID: 11142424

Genes

COMT
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk.PMID 11142424Read ↗

Catechol-O-methyltransferase and breast cancer risk.Semantic proximity Read ↗

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.Semantic proximity Read ↗

Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women.Semantic proximity Read ↗

Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a meta-analysis of 3,940 individuals.Semantic proximity Read ↗

Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls.Semantic proximity Read ↗

Lack of associations of the COMT Val158Met polymorphism with risk of endometrial and ovarian cancer: a pooled analysis of case-control studies.Semantic proximity Read ↗

Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients.Semantic proximity Read ↗

Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer.Semantic proximity Read ↗

Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.Semantic proximity Read ↗

Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.Semantic proximity Read ↗

Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis.Semantic proximity Read ↗

No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women.Semantic proximity Read ↗

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