Article
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
The Journal of clinical investigation - 15 Dec 1998
Korn B S, Shimomura I, Bashmakov Y, Hammer R E, Horton J D, Goldstein J L, Brown M S
Abstract excerpt
Feedback regulation of cholesterol biosynthesis is mediated by membrane-bound transcription factors designated sterol regulatory element-binding proteins (SREBP)-1 and -2. In sterol-deprived cultured cells, SREBPs are released from membranes by a proteolytic process that is stimulated by SREBP cl...
Topics
- Animals
- CCAAT-Enhancer-Binding Proteins
- Cholesterol
- DNA-Binding Proteins
- Diet
- Fatty Acids
- Feedback
- Intracellular Signaling Peptides and Proteins
- Lipid Metabolism
- Liver
- Membrane Proteins
- Mice
- Mice, Transgenic
- Mutation
- Nuclear Proteins