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Article

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

The Journal of clinical investigation - 15 Dec 1998

Korn B S, Shimomura I, Bashmakov Y, Hammer R E, Horton J D, Goldstein J L, Brown M S

Abstract excerpt

Feedback regulation of cholesterol biosynthesis is mediated by membrane-bound transcription factors designated sterol regulatory element-binding proteins (SREBP)-1 and -2. In sterol-deprived cultured cells, SREBPs are released from membranes by a proteolytic process that is stimulated by SREBP cleavage-activating protein (SCAP), a membrane protein containing a sterol-sensing domain. Sterols suppress SREBP...

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Identifiers

PMID: 9854040
DOI: 10.1172/JCI5341
PMCID: PMC509159

Genes

SCAP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).PMID 9854040Read ↗

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.Semantic proximity Read ↗

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.Semantic proximity Read ↗

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.Semantic proximity Read ↗

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.Semantic proximity Read ↗

Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.Semantic proximity Read ↗

SREBPs: sterol-regulated transcription factorsSemantic proximity Read ↗

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.Semantic proximity Read ↗

Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster.Semantic proximity Read ↗

Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice.Semantic proximity Read ↗

SCAP is required for timely and proper myelin membrane synthesis.Semantic proximity Read ↗

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.Semantic proximity Read ↗

A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid.Semantic proximity Read ↗

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