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Article

Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice.

Biochimica et biophysica acta - 5 Apr 2004

Xu Guoqiang, Müller Oliver, Stange Eduard F, Fuchs Michael

Abstract excerpt

Lipid synthesis is under tight transcriptional control involving sterol regulatory element binding proteins (SREBP1, SREBP2). Rising cellular cholesterol levels prevent SREBP2 from entering the nucleus to directly activate the expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), the key enzyme of cholesterol synthesis. The failure to down-regulate cholesterol synthesis in gallstone-susceptible...

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Identifiers

PMID: 15062879
DOI: 10.1016/j.bbadis.2004.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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