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Article

Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice.

Biochimica et biophysica acta - 5 Apr 2004

Xu Guoqiang, Müller Oliver, Stange Eduard F, Fuchs Michael

Abstract excerpt

Lipid synthesis is under tight transcriptional control involving sterol regulatory element binding proteins (SREBP1, SREBP2). Rising cellular cholesterol levels prevent SREBP2 from entering the nucleus to directly activate the expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr),...

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Identifiers

PMID: 15062879
DOI: 10.1016/j.bbadis.2004.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15062879-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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