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Article

A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid.

Journal of biochemistry - 1 May 2014

Nakakuki Masanori, Kawano Hiroyuki, Notsu Tatsuto, Imada Kazunori, Mizuguchi Kiyoshi, Shimano Hitoshi

Abstract excerpt

The proteolytic cascade is the key step in transactivation of sterol regulatory element-binding proteins (SREBPs), a transcriptional factor of lipid synthesis. Proteolysis of SREBP-2 is strictly regulated by sterols, but that of SREBP-1c was not strongly sterol-regulated, but inhibited by polyunsaturated fatty acids (PUFAs). In this study, the proteolytic processing of SREBP-1 and -2 was examined by transfection...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24729033
DOI: 10.1093/jb/mvu019

Genes

SCAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid.PMID 24729033Read ↗

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