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Article

Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster.

Genetics - 1 May 2010

Matthews Krista A, Ozdemir Cafer, Rawson Robert B

Abstract excerpt

The escort factor Scap is essential in mammalian cells for regulated activation of sterol regulatory element binding proteins (SREBPs). SREBPs are membrane-bound transcription factors. Cells lacking Scap cannot activate SREBP. They are therefore deficient in the transcription of numerous genes in...

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Identifiers

PMID: 20176975
DOI: 10.1534/genetics.110.114975
PMCID: PMC2870954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20176975-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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